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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
19/02/2009 |
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Data da última atualização: |
02/03/2009 |
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Tipo da produção científica: |
Capítulo em Livro Técnico-Científico |
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Autoria: |
REGITANO, L. C. A.; IBELLI, A. M. G.; GASPARIN, G.; MIYATA, M.; AZEVEDO, A. L. S.; COUTINHO, L. L.; TEODORO, R. L.; MACHADO, M. A.; SILVA, M. V. G. B.; NAKATA, L. C.; ZAROS, L. G.; SONSTEGARD, T. S.; SILVA, A. M.; ALENCAR, M. M.; OLIVEIRA, M. C. S. |
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Afiliação: |
Luciana Correia de Almeida Regitano - Embrapa Pecuária Sudeste; A.G. Ibelli - UFSCar; Gustavo Gasparin - UFSCar; Yukino Miyata - UFSCar; A. L. S. Azevedo, UFV; Luiz L. Coutinho - ESALQ/USP; Roberto Luiz Teodoro, Embrapa Gado de Leite; Marco Antonio Machado - Embrapa Gado de Leite; Marcus Vinicius G.B. Silva, Embrapa Gado de Leite; L. C. Nakata, UF São Carlos; L. G. Zaros, Esalq; Tad Stewart Sonstegard, USDA/ARS; A. M. Silva, UF São Carlos; Mauricio de Mello Alencar, Embrapa Pecuária Sudeste; M.C.S. Oliveira, Embrapa Pecuária Sudeste. |
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Título: |
On the search for markers of tick resistance in bovines. |
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Ano de publicação: |
2008 |
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Fonte/Imprenta: |
In: PINARD, M.; GAY, C.; PASTORET, P.; DODET, B. (Ed.). Animal genomics for animal healt. Basel, Karger: Dev Biol, 2008. p. 225-230. |
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Volume: |
132 |
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Idioma: |
Inglês |
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Conteúdo: |
Genetic differences in susceptibility to tick (Riphicephalus (Boophilus) microplus) are considerable in bovine. In general, Bos taurus is more susceptible to ticks than Bos indicus. On the search for the molecular basis of tick resistance we used mapping, association and gene expression approaches. A B. taurus x B. indicus F2 population was developed by Embrapa and 300 individuals were measured for parasite load and genotype for microsatellite markers covering chromosomes 5, 7 and 14. A suggestive chromosome-wide QTL for tick load (P < 0.05) was mapped on chromosome 5 and two suggestive (P < 0.10) QTL on chromosome 7 and 14. In the candidate gene approach, females from the genetic groups Nelore (NE -184), Canchim x Nelore (CN -153), Aberdeen Angus x Nelore (AN -123) and Simmental x Nelore (SN -120) were evaluated under natural infestation in seven to ten tick Counts. Microsatellite markers close to the genes for interleukin 2 (IL2), interleukin 4 (IL4) and interferongamma (lFNG) were analysed. Tick counts were associated to the marker for interleukin 4 (P < 0.05) in NE, CN and AN genetic groups. We also investigated if there were differences in cytokine mRNA of naive versus infested Nelore as well as of resistant versus susceptible cows from NE, CN and AN genetic groups. Relative quantification of cytokines from infested compared to naives showed down regulation of IL2. When resistant cows from the from genetic groups were. compared to susceptible animals, IL8 was down regulated but no differences were found for IL4 expression. MenosGenetic differences in susceptibility to tick (Riphicephalus (Boophilus) microplus) are considerable in bovine. In general, Bos taurus is more susceptible to ticks than Bos indicus. On the search for the molecular basis of tick resistance we used mapping, association and gene expression approaches. A B. taurus x B. indicus F2 population was developed by Embrapa and 300 individuals were measured for parasite load and genotype for microsatellite markers covering chromosomes 5, 7 and 14. A suggestive chromosome-wide QTL for tick load (P < 0.05) was mapped on chromosome 5 and two suggestive (P < 0.10) QTL on chromosome 7 and 14. In the candidate gene approach, females from the genetic groups Nelore (NE -184), Canchim x Nelore (CN -153), Aberdeen Angus x Nelore (AN -123) and Simmental x Nelore (SN -120) were evaluated under natural infestation in seven to ten tick Counts. Microsatellite markers close to the genes for interleukin 2 (IL2), interleukin 4 (IL4) and interferongamma (lFNG) were analysed. Tick counts were associated to the marker for interleukin 4 (P < 0.05) in NE, CN and AN genetic groups. We also investigated if there were differences in cytokine mRNA of naive versus infested Nelore as well as of resistant versus susceptible cows from NE, CN and AN genetic groups. Relative quantification of cytokines from infested compared to naives showed down regulation of IL2. When resistant cows from the from genetic groups were. compared to susceptible animals, IL8 was down regul... Mostrar Tudo |
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Palavras-Chave: |
Marcadores genéticos. |
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Thesagro: |
Carrapato; Resistência. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02549naa a2200349 a 4500
001 1596319
005 2009-03-02
008 2008 bl --- 0-- u #d
100 1 $aREGITANO, L. C. A.
245 $aOn the search for markers of tick resistance in bovines.
260 $c2008
300 $a132
490 $v132
520 $aGenetic differences in susceptibility to tick (Riphicephalus (Boophilus) microplus) are considerable in bovine. In general, Bos taurus is more susceptible to ticks than Bos indicus. On the search for the molecular basis of tick resistance we used mapping, association and gene expression approaches. A B. taurus x B. indicus F2 population was developed by Embrapa and 300 individuals were measured for parasite load and genotype for microsatellite markers covering chromosomes 5, 7 and 14. A suggestive chromosome-wide QTL for tick load (P < 0.05) was mapped on chromosome 5 and two suggestive (P < 0.10) QTL on chromosome 7 and 14. In the candidate gene approach, females from the genetic groups Nelore (NE -184), Canchim x Nelore (CN -153), Aberdeen Angus x Nelore (AN -123) and Simmental x Nelore (SN -120) were evaluated under natural infestation in seven to ten tick Counts. Microsatellite markers close to the genes for interleukin 2 (IL2), interleukin 4 (IL4) and interferongamma (lFNG) were analysed. Tick counts were associated to the marker for interleukin 4 (P < 0.05) in NE, CN and AN genetic groups. We also investigated if there were differences in cytokine mRNA of naive versus infested Nelore as well as of resistant versus susceptible cows from NE, CN and AN genetic groups. Relative quantification of cytokines from infested compared to naives showed down regulation of IL2. When resistant cows from the from genetic groups were. compared to susceptible animals, IL8 was down regulated but no differences were found for IL4 expression.
650 $aCarrapato
650 $aResistência
653 $aMarcadores genéticos
700 1 $aIBELLI, A. M. G.
700 1 $aGASPARIN, G.
700 1 $aMIYATA, M.
700 1 $aAZEVEDO, A. L. S.
700 1 $aCOUTINHO, L. L.
700 1 $aTEODORO, R. L.
700 1 $aMACHADO, M. A.
700 1 $aSILVA, M. V. G. B.
700 1 $aNAKATA, L. C.
700 1 $aZAROS, L. G.
700 1 $aSONSTEGARD, T. S.
700 1 $aSILVA, A. M.
700 1 $aALENCAR, M. M.
700 1 $aOLIVEIRA, M. C. S.
773 $tIn: PINARD, M.; GAY, C.; PASTORET, P.; DODET, B. (Ed.). Animal genomics for animal healt. Basel, Karger: Dev Biol, 2008. p. 225-230.
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Registro original: |
Embrapa Gado de Leite (CNPGL) |
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Origem |
Tipo/Formato |
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Registro |
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URL |
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Registro Completo
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Biblioteca(s): |
Embrapa Pecuária Sul. |
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Data corrente: |
20/11/2012 |
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Data da última atualização: |
24/06/2013 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 2 |
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Autoria: |
SANTANA JÚNIOR, M. L.; ELER, J. P.; CARDOSO, F. F.; ALBUQUERQUE, L. G.; FERRAZ, J. B. S. |
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Afiliação: |
UNIVERSIDADE FEDERAL DE MATO GROSSO; USP; FERNANDO FLORES CARDOSO, CPPSUL; UNIVERSIDADE ESTADUAL PAULISTA; USP. |
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Título: |
Phenotypic plasticity of composite beef cattle performance using reaction norms model with unknown covariate. |
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Ano de publicação: |
2013 |
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Fonte/Imprenta: |
Animal, Cambridge, v. 7, n. 2, p. 202-210, Feb. 2013. |
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ISSN: |
1751-732X |
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Idioma: |
Inglês |
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Notas: |
Firstview article 27 set. 2012. |
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Conteúdo: |
The objective of the present study was to determine the presence of genotype by environment interaction (G × E) and to characterize the phenotypic plasticity of birth weight (BW), weaning weight (WW), postweaning weight gain (PWG) and yearling scrotal circumference (SC) in composite beef cattle using the reaction norms model with unknown covariate. The animals were born between 1995 and 2008 on 33 farms located throughout all Brazilian biomes between latitude −7° and −31°, longitude −40° and −63°. The contemporary group was chosen as the environmental descriptor, that is, the environmental covariate of the reaction norms. In general, higher estimates of direct heritability were observed in extreme favorable environments. The mean of direct heritability across the environmental gradient ranged from 0.05 to 0.51, 0.09 to 0.43, 0.01 to 0.43 and from 0.12 to 0.26 for BW, WW, PWG and SC, respectively. The variation in direct heritability observed indicates a different response to selection according to the environment in which the animals of the population are evaluated. The correlation between the level and slope of the reaction norm for BW and PWG was high, indicating that animals with higher average breeding values responded better to improvement in environmental conditions, a fact characterizing a scale of G × E. Low correlation between the intercept and slope was obtained for WW and SC, implying re-ranking of animals in different environments. Genetic variation exists in the sensitivity of animals to the environment, a fact that permits the selection of more plastic or robust genotypes in the population studied. Thus, the G × E is an important factor that should be considered in the genetic evaluation of the present population of composite beef cattle. MenosThe objective of the present study was to determine the presence of genotype by environment interaction (G × E) and to characterize the phenotypic plasticity of birth weight (BW), weaning weight (WW), postweaning weight gain (PWG) and yearling scrotal circumference (SC) in composite beef cattle using the reaction norms model with unknown covariate. The animals were born between 1995 and 2008 on 33 farms located throughout all Brazilian biomes between latitude −7° and −31°, longitude −40° and −63°. The contemporary group was chosen as the environmental descriptor, that is, the environmental covariate of the reaction norms. In general, higher estimates of direct heritability were observed in extreme favorable environments. The mean of direct heritability across the environmental gradient ranged from 0.05 to 0.51, 0.09 to 0.43, 0.01 to 0.43 and from 0.12 to 0.26 for BW, WW, PWG and SC, respectively. The variation in direct heritability observed indicates a different response to selection according to the environment in which the animals of the population are evaluated. The correlation between the level and slope of the reaction norm for BW and PWG was high, indicating that animals with higher average breeding values responded better to improvement in environmental conditions, a fact characterizing a scale of G × E. Low correlation between the intercept and slope was obtained for WW and SC, implying re-ranking of animals in different environments. Genetic... Mostrar Tudo |
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Thesagro: |
Gado de corte. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/77851/1/Cardoso-Animal.pdf
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Marc: |
LEADER 02462naa a2200205 a 4500
001 1940020
005 2013-06-24
008 2013 bl uuuu u00u1 u #d
022 $a1751-732X
100 1 $aSANTANA JÚNIOR, M. L.
245 $aPhenotypic plasticity of composite beef cattle performance using reaction norms model with unknown covariate.$h[electronic resource]
260 $c2013
500 $aFirstview article 27 set. 2012.
520 $aThe objective of the present study was to determine the presence of genotype by environment interaction (G × E) and to characterize the phenotypic plasticity of birth weight (BW), weaning weight (WW), postweaning weight gain (PWG) and yearling scrotal circumference (SC) in composite beef cattle using the reaction norms model with unknown covariate. The animals were born between 1995 and 2008 on 33 farms located throughout all Brazilian biomes between latitude −7° and −31°, longitude −40° and −63°. The contemporary group was chosen as the environmental descriptor, that is, the environmental covariate of the reaction norms. In general, higher estimates of direct heritability were observed in extreme favorable environments. The mean of direct heritability across the environmental gradient ranged from 0.05 to 0.51, 0.09 to 0.43, 0.01 to 0.43 and from 0.12 to 0.26 for BW, WW, PWG and SC, respectively. The variation in direct heritability observed indicates a different response to selection according to the environment in which the animals of the population are evaluated. The correlation between the level and slope of the reaction norm for BW and PWG was high, indicating that animals with higher average breeding values responded better to improvement in environmental conditions, a fact characterizing a scale of G × E. Low correlation between the intercept and slope was obtained for WW and SC, implying re-ranking of animals in different environments. Genetic variation exists in the sensitivity of animals to the environment, a fact that permits the selection of more plastic or robust genotypes in the population studied. Thus, the G × E is an important factor that should be considered in the genetic evaluation of the present population of composite beef cattle.
650 $aGado de corte
700 1 $aELER, J. P.
700 1 $aCARDOSO, F. F.
700 1 $aALBUQUERQUE, L. G.
700 1 $aFERRAZ, J. B. S.
773 $tAnimal, Cambridge$gv. 7, n. 2, p. 202-210, Feb. 2013.
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Registro original: |
Embrapa Pecuária Sul (CPPSUL) |
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